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PB-22 and 5F-PB-22 had been the initial synthetic cannabinoids to include a quinoline substructure and an ester linkage. These compounds are assumed to happen to be synthesized With all the intention of making a artificial cannabinoid prodrug, which could make improvements to absorption and confound detection. Ester bonds are quickly biodegradable through spontaneous or endogenous, nonspecific esterase hydrolysis, that has been typically Utilized in medicinal chemistry to create ester prodrugs.